Inhibition of renin by conformationally restricted analogues of angiotensinogen
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منابع مشابه
Synthesis and In Vitro Leishmanicidal Effects of Conformationally Restricted Analogues of Pentamidine
Four conformationally restricted analogues of pentamidine were prepared. Then, different concentrations (0.039, 0.078, 0.156, 0.312 and 0.625 mg/mL) of each compound and two positive controls (amphotericin B and pentamidine, 0.625 mg/mL), one negative control (culture medium) and one solvent control (DMSO) were prepared and placed in 24-well plates containing 50000 parasite per well. Promastigo...
متن کاملSynthesis and In Vitro Leishmanicidal Effects of Conformationally Restricted Analogues of Pentamidine
Four conformationally restricted analogues of pentamidine were prepared. Then, different concentrations (0.039, 0.078, 0.156, 0.312 and 0.625 mg/mL) of each compound and two positive controls (amphotericin B and pentamidine, 0.625 mg/mL), one negative control (culture medium) and one solvent control (DMSO) were prepared and placed in 24-well plates containing 50000 parasite per well. Promastigo...
متن کاملSolution structure of conformationally restricted vasopressin analogues.
In recent years, a massive effort has been directed towards designing potent and selective antagonists of neurohypophyseal hormones substituted at position 3. Modification of vasopressin at position 3 with 4,4'-biphenylalanine results in pharmacologically inactive analogues. Chemically, this substitution appears to vary only slightly from those previously made by us (1-Nal or 2-Nal), which affo...
متن کاملsynthesis and in vitro leishmanicidal effects of conformationally restricted analogues of pentamidine
four conformationally restricted analogues of pentamidine were prepared. then, different concentrations (0.039, 0.078, 0.156, 0.312 and 0.625 mg/ml) of each compound and two positive controls (amphotericin b and pentamidine, 0.625 mg/ml), one negative control (culture medium) and one solvent control (dmso) were prepared and placed in 24-well plates containing 50000 parasite per well. promastigo...
متن کاملConformationally Restricted Fentanyl Analogs
Synthesis, analgesic activity and preliminary molecular modeling studies of the cisand trans-fused octahydro-l,2,3,4,4a,5,11,1 la-pyrido[3,4-c][1,5]benzoxazepines 8 and 9, the first rigid fentanyl analogs with a conformationally restricted 4-anilido group that retain antinociceptive properties, are reported. Fentanyl (1) is the prototype of the highly potent 4-anilidopiperidine class of synthet...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1982
ISSN: 0264-6021
DOI: 10.1042/bj2050043